Preserve Important Clinical Trial Samples.

As researchers begin to rely more heavily on nucleic acid, metabolite, and biomarker profiles to make diagnostic, prognostic, and therapeutic decisions, biospecimen integrity is becoming more critical. With frozen aliquotting, a wide range of analyses can be performed without exposing samples to harmful freeze-thaw cycles. Testing of frozen aliquots increases sample reproducibility (for improved ISR results) and preserves parent samples for additional testing.

Analyze Unstable Drug Molecules.

5% to 10% of drug molecules are inherently unstable. Frozen aliquotting of tissue and biofluids stabilizes small molecules and peptides for ADME/Tox and DMPK analysis. Deposit frozen aliquots directly into organic solvent for LC/MS-MS analysis. Frozen aliquotting is compatible with a wide range of sample types including tissue, stool, whole blood, serum, plasma, urine and other biofluids.Biomarkers may be relevant only in certain cell types of the same tissue. Frozen aliquotting enables researchers to easily investigate specific tumor or tissue regions and is easily integrated into the traditional pathology work flow. After staining and examination of a tissue sample, specific tissue sections can be targeted for frozen aliquotting and testing. Recent applications include placental tissue/epigenomics (DNA, RNA), melanoma/tumor enrichment and uterine tissue/genomics (RNA).

Enable Retrospective Studies.

Frozen aliquotting enables researchers to both preserve and utilize precious clinical trial and rare disease samples. Capturing a sample aliquot without thawing preserves the integrity of the parent sample and provides sample aliquots for testing in retrospective studies.In most pathology labs, tissues are manually sectioned with a scalpel. Automated coring, or aliquotting, allows researchers to avoid manual slicing of frozen tissue and improve the safety, efficiency, and reproducibility of tissue processing.It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.